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Full Dictionary List Organic Skin Care |
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Mandelic Acid Definition: Mandelic Acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid with the chemical formula HOCH(C6H5)COOH. The mandelic acid molecule is larger than the glycolic acid molecule, a widely used AHA. In addition, mandelic acid, which has a pK of 3.41, is stronger than glycolic acid, which has a pKof 3.83 at 25°C. The acidity of AHAs may vary considerably with changes in temperature. Mandelic Acid has a high melting point, is partially soluble in water, and is freely soluble in isopropyl and ethyl alcohol. Mandelic Acid occurs in two enantiomeric forms that may affect pharmaceutical activity. Mandelic acid has
been used in medicine for many years as a urinary antiseptic. Methenamine mandelate
(Mandelamine®, Parke-Davis, Morris Plains, NJ) has the urinary antiseptic
action of both methenamine and mandelic acid. In concentrations of 35g to50g/100L
of urine, it inhibits Staphylococcus aureus, bacillus proteus, escherichia coli,
and aerobacter aerogenes. Chemically, mandelic acid has a structure similar
to that of other well-known antibiotics. It is a nontoxic substance that, after
being ingested orally, is excreted in the urine. Products that Contain Mandelic Acid:
M2 Skin Refinish 20% |
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